Absolutely never give up. I have been receiving treatment for stage 4 breast cancer for years. There is always hope. I went to MD Anderson Cancer Center in Houston TX. They view cancer completely different than most places. May take some time and effort to get an appt but most places take some time to get an appt. If you can't go to md go to any other cancer research or specialty center. DO NOT GIVE UP!!!!! Just guessing, but I bet the dr who has given up is not an oncologist that specializes in breast cancer. There are so many options, but you have to spend the time and effort to get your sister to the right facility. She IS worth it. Healing prayers for your sister.